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The materials in this collection concern the subject's professional career as a scientist from the 1920s through the 1970s. Newspaper articles and correspondence highlight his professional achievements as well as his responsibilities as head of the A.P. Cooke Memorial Cancer Laboratory, the Citrus Research Laboratory, and the Southern Bio-Research Institute, all located at Florida Southern College. Additionally, this collection contains academic journal articles and papers published by the subject, as well as articles that cited his work. Dr. Sokoloff was a strong proponent of democracy and often wrote about the dangers of communism. Some of these writings can be found within the newspaper articles in this collection

The Boyd family collection contains correspondence, photographs, scrapbooks and awards from the Boyd family. Family papers include those from Gertrude A. Boyd, Catherine Boyd Fahrion and Alice Boyd Stevens.