Collection
- Scarborough Papers, 1868-1945, Date acquired: 06/13/19661
- Senator Duncan U. Fletcher Papers, 1860-1936, Date acquired: 08/06/19651
- Seth A. McKinney collection, 1917-1977, Date acquired: 04/19/1999, bulk 1942-19451
- Sheldon Abend American Theater Collection, 1874-19681
- Sheriff Chad Chronister Hillsborough County Sheriff's Office (HCSO) historical collection, 1920-20001
- Simmons family papers, 1772-1951, Date acquired: 02/00/19621
- Sir Arthur Evans Letter, 1925-04-061
- Sixto Campano Collection, Circa 1848-19741
- Smith Families of Virginia Letters, 1831-19421
- Snodgrass Collection, 1871-1985, Date acquired: 07/00/19851
- Snow Family papers, 1826-19561
- Sociedad la Unión Martí-Maceo records, 1853-2000, 19831
- Society of African Missions Postcard Collection, Circa 1858-19701
- Sol and Sadie Malkoff Papers, 1900-19991
- Southwest Florida Newspaper Collection, bulk 1920-20181
- Southwest Florida Regional Planning Council Collection, 1920-20201
- Spessard Lindsey Holland Papers, 1892-19711
- St. Augustine, Florida Records, 1883-1959, bulk 1930-19401
- St. John's Cemetery Company (Pensacola) Records, 1892-1985, Date acquired: 09/17/19851
- St. Mary's Episcopal Church Collection, 1868-1954, Date acquired: 10/00/19821